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Targeted Allele Detail
Symbol: Patz1tm1.1Welm
Name: POZ (BTB) and AT hook containing zinc finger 1; targeted mutation 1.1, Wilfried Ellmeier
MGI ID: MGI:4454313
Gene: Patz1  Location: Chr11:3289131-3309083 bp, + strand  Genetic Position: Chr11, 2.3 cM
Germline Transmission:  Earliest citation of germline transmission: J:158947
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette was inserted within intron 1 and a single loxP site 5' to exon 1 by homologous recombination. Exon 1 and the neo cassette were removed by cre mediated recombination. (J:158947)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Patz1 Mutation:  29 strains or lines available
From: Wilfried Ellmeier [wilfried.ellmeier@meduniwien.ac.at] Sent: Monday, May 24, 2010 2:24 PM To: Jason Bubier Cc: Wilfried Ellmeier Subject: Re: Information Request Follow Up Flag: Follow Up Flag Status: Flagged Dear Dr. Bubier, Sorry for the delayed reply. We used the widely used E14 ES cell line for the deletion. The floxed MAZR allele was deleted in ES cells with CMV-Cre (using transient transfection), therefore we generated a germ-line knockout. With best wishes, Wilfried Ellmeier
Original:  J:158947 Sakaguchi S, et al., The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes. Nat Immunol. 2010 May;11(5):442-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory