Il22^tm1Jcrd
Targeted Allele Detail

Summary

• Symbol: Il22^tm1Jcrd
• Name: interleukin 22; targeted mutation 1, Jean-Christophe Renauld
• MGI ID: MGI:4453827
• Gene: Il22 Location: Chr10:118040847-118045952 bp, + strand Genetic Position: Chr10, 66.67 cM
• Alliance: Il22^tm1Jcrd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155038
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Coding exons 1a, 1b, 2, and a part of exon 3 were replace with a neo cassette by homologous recombination. Absence of RNA and protein was confirmed by RT-PCR and ELISA. (J:155038)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il22 Mutation: 27 strains or lines available

References

• Original: J:155038 Kreymborg K, et al., IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J Immunol. 2007 Dec 15;179(12):8098-104
• All: 22 reference(s)