Tshr^hyt-2J
Spontaneous Allele Detail

Summary

• Symbol: Tshr^hyt-2J
• Name: thyroid stimulating hormone receptor; hypothyroid 2 Jackson
• MGI ID: MGI:4453218
• Gene: Tshr Location: Chr12:91367767-91507283 bp, + strand Genetic Position: Chr12, 44.51 cM
• Alliance: Tshr^hyt-2J page

Mutation origin

• Strain of Origin: (C57BL/6J-A^w-J x 129P3/J)F2/J

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Single point mutation
• Mutation details: This spontaneous C-to-T transition in chromosome 12 position 91,537,844 bp (GRCm38) causes a premature stop codon in exon 10 at arginine 519 (p.R519*), resulting in a loss of at least the transmembrane portion of the encoded protein. (J:213054)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tshr Mutation: 7 strains or lines available

References

• Original: J:213054 Dionne LA, et al., The hypothyroid 2 Jackson mutation. MGI Direct Data Submission. 2014
• All: 1 reference(s)