About   Help   FAQ
Ikbkbtm2.1Mka
Targeted Allele Detail
Nomenclature
Symbol: Ikbkbtm2.1Mka
Name: inhibitor of kappaB kinase beta; targeted mutation 2.1, Michael Karin
MGI ID: MGI:4453210
Synonyms: IKKbetadelta
Gene: Ikbkb  Location: Chr8:22659212-22706589 bp, - strand  Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88644
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe floxed exon 3 in Ikbkbtm2Mka was removed via cre-mediated recombination by breeding with Tg(Vil-cre)1Mka mice. Although this cre transgene is expressed in the small intestinal epithelial and colon epithelial cells, a small amount of cre recombination occurred in the testis resulting in germline transmission of the exon 3 deleted allele. (J:82995, J:88644)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikbkb Mutation:  33 strains or lines available
Notes
ES cell line = GS (Genome Systems).
References
Original:  J:88644 Egan LJ, et al., IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2452-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/11/2017
MGI 6.10
The Jackson Laboratory