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Ikbkbtm2.1Mka
Targeted Allele Detail
Nomenclature
Symbol: Ikbkbtm2.1Mka
Name: inhibitor of kappaB kinase beta; targeted mutation 2.1, Michael Karin
MGI ID: MGI:4453210
Synonyms: IKKbetadelta
Gene: Ikbkb  Location: Chr8:22659212-22706589 bp, - strand  Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88644
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe floxed exon 3 in Ikbkbtm2Mka was removed via cre-mediated recombination by breeding with Tg(Vil-cre)1Mka mice. Although this cre transgene is expressed in the small intestinal epithelial and colon epithelial cells, a small amount of cre recombination occurred in the testis resulting in germline transmission of the exon 3 deleted allele. (J:82995, J:88644)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikbkb Mutation:  31 strains or lines available
Notes
ES cell line = GS (Genome Systems).
References
Original:  J:88644 Egan LJ, et al., IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2452-7
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory