Tg(Prnp-ITM2B*)7Jckr
Transgene Detail

Summary

• Symbol: Tg(Prnp-ITM2B*)7Jckr
• Name: transgene insertion 7, Mathias Jucker
• MGI ID: MGI:4452483
• Synonyms: ADanPP7, Tg(SHaPrP-BRI2795InsTTTAATTTGT)
• Transgene: Tg(Prnp-ITM2B*)7Jckr Location: unknown
• Alliance: Tg(Prnp-ITM2B*)7Jckr page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-ITM2B*)7Jckr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ITM2B (9445)

  Itm2b

  (MGI:1309517)

  The gene encodes the Danish allele

• Mutation details: This transgene expresses the Danish allele of human ITM2B, which includes a 10-nucleotide duplication (795-796InsTTTAATTTGT) in ITM2B, driven by the Syrian hamster Prnp promoter. Two lines were created (lines 6 and 7) with line 7 exhibiting high levels of transgene expression. (J:159279)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:159279 Coomaraswamy J, et al., Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7969-74
• All: 2 reference(s)