Igh^tm4.1Mnz
Targeted Allele Detail

Summary

• Symbol: Igh^tm4.1Mnz
• Name: immunoglobulin heavy chain complex; targeted mutation 4.1, Michel C Nussenzweig
• MGI ID: MGI:4452369
• Synonyms: IgH^96k
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159173
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J

Mutation description

Allele Type: Targeted (Not Applicable) Mutation: Insertion Mutation details: An frt-flanked neo cassette with 5' loxP and I-SceI site was inserted into the 3' Ighg1 switch region. Flp mediated recombination removed the neo cassette leaving the single loxP site. ES cells originally used to create this allele also contained Igh^tm3Mnz 96 kb upstream. (J:159173)

Generation of the Igh^tm4.1Mnz allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 43 strains or lines available

References

• Original: J:159173 Bothmer A, et al., 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. J Exp Med. 2010 Apr 12;207(4):855-65
• All: 6 reference(s)