Wls^tm1.1Lan
Targeted Allele Detail

Summary

• Symbol: Wls^tm1.1Lan
• Name: wntless WNT ligand secretion mediator; targeted mutation 1.1, Richard A Lang
• MGI ID: MGI:4452362
• Synonyms: Wls^flox
• Gene: Wls Location: Chr3:159545309-159644300 bp, + strand Genetic Position: Chr3, 82.65 cM
• Alliance: Wls^tm1.1Lan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164701
• Parent Cell Line: Duffy (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of the coding sequence in exon 1, followed by an frt-flanked neomycin resistance (neo) cassette and a second loxP site upstream of exon 2 of the wntless homolog (Drosophila) (Wls) gene. Flp mediated recombination removed the neo cassette leaving the coding sequence of exon 1 floxed. (J:164701)

Expression

In Mice Carrying this Mutation:	112 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wls Mutation: 38 strains or lines available

References

• Original: J:164701 Carpenter AC, et al., Generation of mice with a conditional null allele for Wntless. Genesis. 2010 Sep;48(9):554-8
• All: 68 reference(s)