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Wlstm1.1Lan
Targeted Allele Detail
Nomenclature
Symbol: Wlstm1.1Lan
Name: wntless WNT ligand secretion mediator; targeted mutation 1.1, Richard A Lang
MGI ID: MGI:4452362
Synonyms: Wlsflox
Gene: Wls  Location: Chr3:159839672-159938664 bp, + strand  Genetic Position: Chr3, 82.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:164701
Parent Cell Line:  Duffy (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a loxP site upstream of the coding sequence in exon 1, followed by an frt-flanked neomycin resistance (neo) cassette and a second loxP site upstream of exon 2 of the wntless homolog (Drosophila) (Wls) gene. Flp mediated recombination removed the neo cassette leaving the coding sequence of exon 1 floxed. (J:164701)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 35 assay results
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Wls Mutation:  26 strains or lines available
References
Original:  J:164701 Carpenter AC, et al., Generation of mice with a conditional null allele for Wntless. Genesis. 2010 Sep;48(9):554-8
All:  46 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory