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Transgene Detail
Symbol: Tg(Myh6-STK4*K59R)10Jusa
Name: transgene insertion 10, Junichi Sadoshima
MGI ID: MGI:4452341
Synonyms: Tg-DN-Mst1, Tg(Myh6-MST1*K59R)10Jusa
Transgene: Tg(Myh6-STK4*K59R)10Jusa  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Myh6-STK4*K59R)10Jusa expresses 1 gene
Mutation detailsThe mouse promoter drives cardiac-specific expression of the human CDNA with nucleotide substitutions that result in the amino acid substitution of arginine for lysine at position 49 (K59R). Three lines were created (lines 9, 10, and 11) with line 10 exhibiting high expression levels and lines 9 and 11 exhibiting low expression levels. (J:139414)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:139414 Yamamoto S, et al., Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest. 2003 May;111(10):1463-74
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory