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Targeted Allele Detail
Symbol: Sfntm1Mul
Name: stratifin; targeted mutation 1, William J Muller
MGI ID: MGI:4452136
Synonyms: 14-3-3sigmaF
Gene: Sfn  Location: Chr4:133600556-133602168 bp, - strand  Genetic Position: Chr4, 66.25 cM, cytoband D3
Germline Transmission:  Earliest citation of germline transmission: J:159517
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe first 434 coding base pairs of the single exon with a 5' loxP site was followed by SV40 PolyA signal with a downstream loxP site, and followed by a PGK neomycin selection cassette. Homozygous mice showed significantly reduced mRNA levels in mammary glands, although no apparent developmental or functional differences were observed. (J:159517)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sfn Mutation:  11 strains or lines available
Original:  J:159517 Ling C, et al., A novel role for 14-3-3sigma in regulating epithelial cell polarity. Genes Dev. 2010 May;24(9):947-56
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory