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Slc2a8tm1.1Asch
Targeted Allele Detail
Nomenclature
Symbol: Slc2a8tm1.1Asch
Name: solute carrier family 2, (facilitated glucose transporter), member 8; targeted mutation 1.1, Annette Schuermann
MGI ID: MGI:4450978
Synonyms: GLUT8 knockout, Slc2a8-
Gene: Slc2a8  Location: Chr2:32972990-32982083 bp, - strand  Genetic Position: Chr2, 22.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159441
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 5 and another downstream of exon 7; a PGK-neo/HSV-tk cassette (neo/tk) followed by a third loxP site was inserted in intron 7 further downstream. The present allele was generated by Cre recombinase excision of the neo/tk cassette and exons 5 through 7 of the endogenous gene. (J:159441)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc2a8 Mutation:  8 strains or lines available
References
Original:  J:159441 Gawlik V, et al., Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa. Mol Membr Biol. 2008 Apr;25(3):224-35
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory