Grin2b^tm1.1Jlbr
Targeted Allele Detail

Summary

• Symbol: Grin2b^tm1.1Jlbr
• Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2); targeted mutation 1.1, Jonathan L Brigman
• MGI ID: MGI:4443321
• Synonyms: GluN2B-floxed
• Gene: Grin2b Location: Chr6:135690231-136150509 bp, - strand Genetic Position: Chr6, 66.38 cM
• Alliance: Grin2b^tm1.1Jlbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159387
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of the 599 bp exon (exon 3 or 5 depending on the gene model) and a loxP site was inserted downstream of the exon. Cre mediated recombination removed the neo cassette leaving the exon floxed. (J:159387)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin2b Mutation: 96 strains or lines available

References

• Original: J:159387 Brigman JL, et al., Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. J Neurosci. 2010 Mar 31;30(13):4590-600
• All: 11 reference(s)