Dok3^tm1Ppp
Targeted Allele Detail

Summary

• Symbol: Dok3^tm1Ppp
• Name: docking protein 3; targeted mutation 1, Pier Paolo Pandolfi
• MGI ID: MGI:4443003
• Gene: Dok3 Location: Chr13:55671044-55677109 bp, - strand Genetic Position: Chr13, 30.06 cM
• Alliance: Dok3^tm1Ppp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158011
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exons 3-5 were disrupted by insertion of a cassette containing GFP (in frame) and neo (in reverse orientation). No GFP expression was detected in lung or peripheral blood. The absence of protein expression was confirmed by western blot analysis on splenocyte extracts. (J:158011)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Dok3^tm1Ppp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dok3 Mutation: 18 strains or lines available

References

• Original: J:158011 Berger AH, et al., Identification of DOK genes as lung tumor suppressors. Nat Genet. 2010 Mar;42(3):216-23
• All: 3 reference(s)