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Arl6tm1Vcs
Targeted Allele Detail
Nomenclature
Symbol: Arl6tm1Vcs
Name: ADP-ribosylation factor-like 6; targeted mutation 1, Val C Sheffield
MGI ID: MGI:4442928
Synonyms: Bbs3L-
Gene: Arl6  Location: Chr16:59612949-59639391 bp, - strand  Genetic Position: Chr16, 34.83 cM, cytoband C1.2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159222
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsThe splice acceptor and splice donor sites of exon 8 were mutated (AG->AC and GT->CT, respectively) and a neo cassette was inserted downstream of the modified exon 8. The nucleotide substitutions are predicted to result in the exclusion of exon 8 of the long transcript. RT-PCR confirmed the expression of the modified allele. (J:159222)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Arl6 Mutation:  7 strains or lines available
References
Original:  J:159222 Pretorius PR, et al., Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform. PLoS Genet. 2010;6(3):e1000884
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory