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Trp73tm2Mak
Targeted Allele Detail
Nomenclature
Symbol: Trp73tm2Mak
Name: transformation related protein 73; targeted mutation 2, Tak Mak
MGI ID: MGI:4442798
Synonyms: deltaNp73-
Gene: Trp73  Location: Chr4:154056253-154140208 bp, - strand  Genetic Position: Chr4, 83.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157905
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Modified isoform(s), Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3' was replaced with a neo cassette by homologous recombination. This targets the delta Np73 isoforms but not TAp73 isoforms. The loss of Np73 isoform mRNA expression was confirmed by quantitative RT-PCR in MEFs and western blot analysis of lung tissue confirmed loss of isoform specific protein expression. Quantitative RT-PCR of liver, testis, and lung confirmed the retention of TAp73 isoform mRNA expression. (J:157905)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp73 Mutation:  5 strains or lines available
References
Original:  J:157905 Wilhelm MT, et al., Isoform-specific p73 knockout mice reveal a novel role for {Delta}Np73 in the DNA damage response pathway. Genes Dev. 2010 Mar 15;24(6):549-60
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory