Fzd7^tm1.1Nat
Targeted Allele Detail

Summary

• Symbol: Fzd7^tm1.1Nat
• Name: frizzled class receptor 7; targeted mutation 1.1 Jeremy Nathans
• MGI ID: MGI:4442616
• Synonyms: Fz7^lacZ, Fzd7^NLS
• Gene: Fzd7 Location: Chr1:59521583-59526114 bp, + strand Genetic Position: Chr1, 30.08 cM
• Alliance: Fzd7^tm1.1Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159435
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame of the targeted gene was replaced by nuclear-localized beta-galactosidase (nLacZ; using an SV40 nuclear localization signal) using homologous recombination in a 129-derived embryonic stem (ES) cell line. A LoxP-flanked neomycin selectable marker used for ES cell selection was removed by subsequent crossing to a mouse line expressing germline Cre recombinase. (J:159435, J:189062)

Expression

In Mice Carrying this Mutation:	12 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fzd7 Mutation: 35 strains or lines available

References

• Original: J:159435 Nathans J, DDS for Fzd7^tm1.1Nat. MGI Direct Data Submission. 2010
• All: 5 reference(s)