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Fzd7tm1.1Nat
Targeted Allele Detail
Nomenclature
Symbol: Fzd7tm1.1Nat
Name: frizzled class receptor 7; targeted mutation 1.1 Jeremy Nathans
MGI ID: MGI:4442616
Synonyms: Fz7lacZ, Fzd7NLS
Gene: Fzd7  Location: Chr1:59521583-59526114 bp, + strand  Genetic Position: Chr1, 30.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159435
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe open reading frame of the targeted gene was replaced by nuclear-localized beta-galactosidase (nLacZ; using an SV40 nuclear localization signal) using homologous recombination in a 129-derived embryonic stem (ES) cell line. A LoxP-flanked neomycin selectable marker used for ES cell selection was removed by subsequent crossing to a mouse line expressing germline Cre recombinase. (J:159435, J:189062)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fzd7 Mutation:  24 strains or lines available
References
Original:  J:159435 Nathans J, DDS for Fzd7tm1.1Nat. MGI Direct Data Submission. 2010;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory