About   Help   FAQ
Targeted Allele Detail
Symbol: Slc32a1tm1.1Bgc
Name: solute carrier family 32 (GABA vesicular transporter), member 1; targeted mutation 1.1, Brian G Condie
MGI ID: MGI:4442415
Synonyms: ViaatlacZ
Gene: Slc32a1  Location: Chr2:158610767-158615748 bp, + strand  Genetic Position: Chr2, 78.72 cM, cytoband H1-3
Cleft palate and umbilical hernia in Slc32a1tm1.1Bgc/Slc32a1tm1.1Bgc mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:158888
Parent Cell Line:  GSI-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA lacZ and floxed neo cassette were inserted into an NcoI site in exon 1 that includes the start site via homologous recombination. The neo was removed by Cre mediated recombination. RT-PCR confirmed the absence of transcript in homozygous mice. (J:158888)
Generation of the Slc32a1tm1.1Bgc allele
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc32a1 Mutation:  14 strains or lines available
Original:  J:158888 Oh WJ, et al., Cleft palate is caused by CNS dysfunction in Gad1 and Viaat knockout mice. PLoS One. 2010;5(3):e9758
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.16
The Jackson Laboratory