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Targeted Allele Detail
Symbol: Ptentm2.1Gle
Name: phosphatase and tensin homolog; targeted mutation 2.1, Gustavo Leone
MGI ID: MGI:4442331
Synonyms: PtenG129E
Gene: Pten  Location: Chr19:32757497-32826160 bp, + strand  Genetic Position: Chr19, 28.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:158751
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe codon GGA for Glycine 129 within exon 5, was mutated to GAA for Glutamate. In addition a floxed neo cassette was introduced within intron 4. The selection cassette was removed by cre mediated recombination. (J:158751)
Generation, targeting, and verification of point mutations of Pten alleles.
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  36 strains or lines available
Original:  J:158751 Wang H, et al., Allele-specific tumor spectrum in Pten knockin mice. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5142-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory