Pten^tm1.2Mwst
Targeted Allele Detail

Summary

• Symbol: Pten^tm1.2Mwst
• Name: phosphatase and tensin homolog; targeted mutation 1.2, Michael Weinstein
• MGI ID: MGI:4442327
• Synonyms: Pten^delta4-5
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm1.2Mwst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158751
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4 and a floxed neo allele was inserted downstream of exon 5. Cre mediated recombination removed the neo cassette and exons 4 and 5. (J:158751)

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pten^tm1.2Mwst

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 81 strains or lines available

References

• Original: J:158751 Wang H, et al., Allele-specific tumor spectrum in Pten knockin mice. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5142-7
• All: 3 reference(s)