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Chd6tm1.2Fier
Targeted Allele Detail
Nomenclature
Symbol: Chd6tm1.2Fier
Name: chromodomain helicase DNA binding protein 6; targeted mutation 1.2, Steven Fiering
MGI ID: MGI:4442238
Gene: Chd6  Location: Chr2:160946978-161109075 bp, - strand  Genetic Position: Chr2, 80.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158513
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S1/SvImJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed and FRT flanked neomycin cassette was inserted 5' to exon 12 and third loxP site inserted 3' to exon 12. The selection cassette and exon 12 were removed by cre mediated recombination. This deletion removes 81 amino acids of the SWI2/SNF2-like domain which encodes motif I, a key ATP-binding motif, and motif Ia, which has DNA-binding activity. The modified protein is produced at wild type levels. (J:158513)
Generation of a Chd6 Exon 12 -/- mouse line.
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chd6 Mutation:  64 strains or lines available
References
Original:  J:158513 Lathrop MJ, et al., Deletion of the Chd6 exon 12 affects motor coordination. Mamm Genome. 2010 Apr;21(3-4):130-42
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory