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Tg(CAG-Bgeo,-tsA58T)T26Ichi
Transgene Detail
Nomenclature
Symbol: Tg(CAG-Bgeo,-tsA58T)T26Ichi
Name: transgene insertion T26, Hirotake Ichise
MGI ID: MGI:4442215
Synonyms: CAG-Betageo-TsA58T tg, LBSL-tsTAg, T26 Tg
Transgene: Tg(CAG-Bgeo,-tsA58T)T26Ichi  Location: unknown  
Transgene
origin
Germline Transmission:  Earliest citation of germline transmission: J:159206
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgene construct has a loxP-flanked Beta-geo gene driven by the CAG promoter, followed by the SV40 tsA58 large T antigen (cDNA for the SV40 TAg and the 3' portion of tsA58T antigen sequence with the A438V mutation.) In the absence of cre-mediated recombination, Beta-geo is expressed and detected by X-gal staining. Removal of the loxP-flanked Beta-geo results in expression of the tsA58T antigen, leading to temperature-dependent cell-type independent cell proliferation, (J:159206)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:159206 Yamaguchi T, et al., Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse. FEBS J. 2008 May;275(9):1988-98
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory