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Ptprcltng
Chemically induced Allele Detail
Nomenclature
Symbol: Ptprcltng
Name: protein tyrosine phosphatase, receptor type, C; lightning
MGI ID: MGI:4441612
Synonyms: PtprcL
Gene: Ptprc  Location: Chr1:138062861-138175708 bp, - strand  Genetic Position: Chr1, 60.73 cM
Mutation
origin
Strain of Origin:  C57BL/6
Project Collection: APF ENU Mutagenesis
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Nucleotide substitutions
 
Mutation detailsENU induced at T to C transition that results in the amino acid substitution of serine for phenylalanine at position 503 (F503S). Flow cytometry confirmed that protein half-life is reduced. (J:158876)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ptprc Mutation:  53 strains or lines available
References
Original:  J:158876 Zikherman J, et al., CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity. 2010 Mar 26;32(3):342-54
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory