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Fntbtm1.2Mbrg
Targeted Allele Detail
Nomenclature
Symbol: Fntbtm1.2Mbrg
Name: farnesyltransferase, CAAX box, beta; targeted mutation 1.2, Martin O Bergo
MGI ID: MGI:4441483
Synonyms: Fntbdelta
Gene: Fntb  Location: Chr12:76765589-76921412 bp, + strand  Genetic Position: Chr12, 33.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158937
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTwo loxP sites were inserted 1kb upstream and 1kb downstream of exon 1, followed by a floxed neo cassette. Neo cassette and exon1 with the promoter sequence were deleted by sequential Cre-mediated recombination. (J:158937)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fntb Mutation:  219 strains or lines available
References
Original:  J:158937 Liu M, et al., Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6471-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory