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Fli1tm1Matr
Targeted Allele Detail
Nomenclature
Symbol: Fli1tm1Matr
Name: Friend leukemia integration 1; targeted mutation 1, Maria Trojanowska
MGI ID: MGI:4441373
Synonyms: Fli1flox
Gene: Fli1  Location: Chr9:32422204-32542861 bp, - strand  Genetic Position: Chr9, 17.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158658
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3 and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Flp mediated recombination removed the neo cassette leaving exons 3 and 4 floxed. (J:158658)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fli1 Mutation:  15 strains or lines available
References
Original:  J:158658 Asano Y, et al., Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy. Am J Pathol. 2010 Apr;176(4):1983-98
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory