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Sp2tm1.2Sus
Targeted Allele Detail
Nomenclature
Symbol: Sp2tm1.2Sus
Name: Sp2 transcription factor; targeted mutation 1.2, Guntram Suske
MGI ID: MGI:4441280
Synonyms: Sp2null
Gene: Sp2  Location: Chr11:96953341-96982959 bp, - strand  Genetic Position: Chr11, 60.17 cM, cytoband D
Small size, failure of embryo turning, and open cranial neural tube in Sp2tm1.2Sus/Sp2tm1.2Sus embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158671
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (C57BL/6 x 129P2/OlaHsd)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTwo loxP sites were inserted to flank exon 3 of the gene, followed by an SA-IRES-lacZ-neo-SVpA cassette and a third loxP site after the cassette in intron 3. The flanked exon 3 and SA-IRES-lacZ-neo-SVpA cassette were deleted by Cre mediated recombination. (J:158671)
Generation of the Sp2tm1.2Sus allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sp2 Mutation:  145 strains or lines available
References
Original:  J:158671 Baur F, et al., Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts. PLoS One. 2010;5(3):e9587
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory