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Tubb3tm1.1Ece
Targeted Allele Detail
Nomenclature
Symbol: Tubb3tm1.1Ece
Name: tubulin, beta 3 class III; targeted mutation 1.1, Elizabeth C Engle
MGI ID: MGI:4441058
Synonyms: TUBB3R262C
Gene: Tubb3  Location: Chr8:123411424-123422015 bp, + strand  Genetic Position: Chr8, 72.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158992
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4 was replaced with a loxP site and an exon 4, which contains nucleotide substitutions resulting in the amino acid substitution of cysteine for arginine at position 262 (R262C). An frt and loxP flanked neo cassette downstream of the modified exon 4 was removed by flp mediated recombination leaving the modified exon 4 floxed. Reduced protein expression was confirmed by western blot analysis on extracts from homozygous and heterozygous mice. (J:158992)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tubb3 Mutation:  11 strains or lines available
References
Original:  J:158992 Tischfield MA, et al., Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell. 2010 Jan 8;140(1):74-87
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory