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Tg(Eno2-MFN2*R94Q)L51Ugfm
Transgene Detail
Nomenclature
Symbol: Tg(Eno2-MFN2*R94Q)L51Ugfm
Name: transgene insertion L51, University of Geneva Faculty of Medicine
MGI ID: MGI:4440895
Synonyms: hMFN2R94QL51, MitoCharc1, mitofusin2R94Q
Transgene: Tg(Eno2-MFN2*R94Q)L51Ugfm  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Eno2-MFN2*R94Q)L51Ugfm expresses 1 gene
 
Mutation detailsThe MitoCharc1 transgene was designed with the human Mitofusin 2 (MNF2) gene driven by a rat enolase (Eno2) promoter. Amino acid 94 of MNF2 was mutated from an Arginine (R) to a Glutamine (Q) to mimic the most commonly mutated residue in Charcot-Marie-Tooth disease type 2A (CMT2A). Line L51 was established. (J:158936)
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:158936 University of Geneva Faculty of Medicine, DDS for transgene from Ugfm. MGI Direct Data Submission. 2010;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory