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Targeted Allele Detail
Symbol: Bhlhe22tm1Meg
Name: basic helix-loop-helix family, member e22; targeted mutation 1, Michael E Greenberg
MGI ID: MGI:4440742
Synonyms: Bhlhb5-
Gene: Bhlhe22  Location: Chr3:18054174-18057517 bp, + strand  Genetic Position: Chr3, 4.98 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:158273
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe single exon of Bhlhe22 was replaced with a PGK-neo cassette by homologous recombination in ES cells, resulting in a null allele. (J:158273)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bhlhe22 Mutation:  7 strains or lines available
Original:  J:158273 Ross SE, et al., Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron. 2010 Mar 25;65(6):886-98
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory