About   Help   FAQ
Sec24bY613X
Chemically induced Allele Detail
Nomenclature
Symbol: Sec24bY613X
Name: Sec24 related gene family, member B (S. cerevisiae); Tyr613Stop
MGI ID: MGI:4440619
Synonyms: Sec24b811, Sec24bY613
Gene: Sec24b  Location: Chr3:129776408-129855202 bp, - strand  Genetic Position: Chr3, 59.87 cM
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis induced a T to A transversion in exon 9 (1834T>A in ENSMUST00000098616). This mutation results in an amino acid substitution of a stop codon at position 613 in a Sec23/24-binding domain instead of tyrosine (Y613X). (J:158452)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sec24b Mutation:  44 strains or lines available
References
Original:  J:158452 Merte J, et al., Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. Nat Cell Biol. 2010 Jan;12(1):41-6; sup pp 1-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/30/2021
MGI 6.17
The Jackson Laboratory