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Bidtm1.1Ast
Targeted Allele Detail
Nomenclature
Symbol: Bidtm1.1Ast
Name: BH3 interacting domain death agonist; targeted mutation 1.1, Andreas Strasser
MGI ID: MGI:4440571
Synonyms: Bid-
Gene: Bid  Location: Chr6:120891930-120916853 bp, - strand  Genetic Position: Chr6, 57.02 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158191
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe allele was created by crossing heterozygous Bidtm1Ast mice with Tg(CMV-cre)1Cgn cre deleter mice to remove neo cassette, leaving a single loxP site and deleting approximately 4.5 kb region of the bid locus containing exons 1 and 2 plus part of exon 3, including the crucial BH3 domain. Western blot analysis on spleen and thymus samples and thymocytes derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:158191)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bid Mutation:  37 strains or lines available
References
Original:  J:158191 Kaufmann T, et al., The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest. Cell. 2007 Apr 20;129(2):423-33
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory