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Dapk1tm1Akc
Targeted Allele Detail
Nomenclature
Symbol: Dapk1tm1Akc
Name: death associated protein kinase 1; targeted mutation 1, Adi Kimchi
MGI ID: MGI:4440532
Synonyms: DAPk-
Gene: Dapk1  Location: Chr13:60601947-60763191 bp, + strand  Genetic Position: Chr13, 32.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158109
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neo cassette was inserted into the first exon of the gene. Gene deletion was confirmed by PCR, western blot and northern blot analysis. (J:158109)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dapk1 Mutation:  33 strains or lines available
References
Original:  J:158109 Gozuacik D, et al., DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Cell Death Differ. 2008 Dec;15(12):1875-86
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory