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Targeted Allele Detail
Symbol: Clic1tm1.1Breit
Name: chloride intracellular channel 1; targeted mutation 1.1, Samuel Breit
MGI ID: MGI:4440469
Gene: Clic1  Location: Chr17:35049966-35058749 bp, + strand  Genetic Position: Chr17, 18.58 cM
Germline Transmission:  Earliest citation of germline transmission: J:158394
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn N-terminal FLAG tag was added after the start codon within exon 2 and a single loxP site was inserted in intron 1 within the 5' UTR. A loxP flanked neo was inserted within intron 5. The selection cassette and exons 2-5 were removed by dre mediated recombination. Northern and Western blotting of various organs demonstrated that there was no transcription or translation. (J:158394)
Generation of the Clic1tm1Breit and Clic1tm1.1Breit alleles
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clic1 Mutation:  8 strains or lines available
Original:  J:158394 Qiu MR, et al., Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene. Genesis. 2010 Feb;48(2):127-36
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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