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Clic1tm1.1Breit
Targeted Allele Detail
Nomenclature
Symbol: Clic1tm1.1Breit
Name: chloride intracellular channel 1; targeted mutation 1.1, Samuel Breit
MGI ID: MGI:4440469
Gene: Clic1  Location: Chr17:35049966-35058749 bp, + strand  Genetic Position: Chr17, 18.58 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158394
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn N-terminal FLAG tag was added after the start codon within exon 2 and a single loxP site was inserted in intron 1 within the 5' UTR. A loxP flanked neo was inserted within intron 5. The selection cassette and exons 2-5 were removed by dre mediated recombination. Northern and Western blotting of various organs demonstrated that there was no transcription or translation. (J:158394)
Generation of the Clic1tm1Breit and Clic1tm1.1Breit alleles
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clic1 Mutation:  8 strains or lines available
References
Original:  J:158394 Qiu MR, et al., Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene. Genesis. 2010 Feb;48(2):127-36
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory