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Targeted Allele Detail
Symbol: Lgi1tm1.1Jkc
Name: leucine-rich repeat LGI family, member 1; targeted mutation 1.1, John K Cowell
MGI ID: MGI:4439515
Gene: Lgi1  Location: Chr19:38264536-38312214 bp, + strand  Genetic Position: Chr19, 32.9 cM
Germline Transmission:  Earliest citation of germline transmission: J:158715
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre mediated recombination removed exons 3 through 8 of a MICER clone with a K14-Agouti gene, 3'Hprt, loxP site, and puro cassette inserted downstream of a duplicated exons 1 and 2 and a neo cassette, loxP site, 5'Hprt, and tyrosinase gene inserted downstream of exon 8. The absence of transcript expression was confirmed by RT-PCR analysis on hippocampus and cortex extracts. (J:158715)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lgi1 Mutation:  19 strains or lines available
Original:  J:158715 Yu YE, et al., Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability. Hum Mol Genet. 2010 May 1;19(9):1702-11
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
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