Lgi1^tm1.1Jkc
Targeted Allele Detail

Summary

• Symbol: Lgi1^tm1.1Jkc
• Name: leucine-rich repeat LGI family, member 1; targeted mutation 1.1, John K Cowell
• MGI ID: MGI:4439515
• Gene: Lgi1 Location: Chr19:38253135-38297387 bp, + strand Genetic Position: Chr19, 32.9 cM
• Alliance: Lgi1^tm1.1Jkc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158715
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed exons 3 through 8 of a MICER clone with a K14-Agouti gene, 3'Hprt, loxP site, and puro cassette inserted downstream of a duplicated exons 1 and 2 and a neo cassette, loxP site, 5'Hprt, and tyrosinase gene inserted downstream of exon 8. The absence of transcript expression was confirmed by RT-PCR analysis on hippocampus and cortex extracts. (J:158715)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lgi1 Mutation: 32 strains or lines available

References

• Original: J:158715 Yu YE, et al., Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability. Hum Mol Genet. 2010 May 1;19(9):1702-11
• All: 5 reference(s)