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Gene trapped Allele Detail
Symbol: Sh3pxd2bGt(GST_1527_E5)Lex
Name: SH3 and PX domains 2B; gene trap GST_1527_E5, Lexicon Genetics
MGI ID: MGI:4439499
Gene: Sh3pxd2b  Location: Chr11:32347820-32428173 bp, + strand  Genetic Position: Chr11, 18.89 cM
Mutant Cell Line:  GST_1527_E5 (Lexicon Genetics)
Germline Transmission:  Earliest citation of germline transmission: J:158635
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Project Collection: Lexicon
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: VICTR48     Vector Type: gene trap
Mutation detailsThe gene trap vector inserted between exon 3 and 4. The absence of protein expression was confirmed by western blot analysis on E12.5 fibroblast extracts. (J:158635)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh3pxd2b Mutation:  4 strains or lines available
Original:  J:158635 Iqbal Z, et al., Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome. Am J Hum Genet. 2010 Feb 12;86(2):254-61
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory