Trpv2^tm1Mijc
Targeted Allele Detail

Summary

• Symbol: Trpv2^tm1Mijc
• Name: transient receptor potential cation channel, subfamily V, member 2; targeted mutation 1, Michael J Caterina
• MGI ID: MGI:4439393
• Gene: Trpv2 Location: Chr11:62465312-62491131 bp, + strand Genetic Position: Chr11, 38.48 cM, cytoband B2
• Alliance: Trpv2^tm1Mijc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158505
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: DNA encoding transmembrane domains 5 and 6 and the intervening loops was removed. The absence of protein expression was confirmed by western blot analysis on peritoneal macrophage extracts. (J:158505)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpv2 Mutation: 40 strains or lines available

References

• Original: J:158505 Link TM, et al., TRPV2 has a pivotal role in macrophage particle binding and phagocytosis. Nat Immunol. 2010 Mar;11(3):232-9
• All: 8 reference(s)