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Pgrtm4.2Lyd
Targeted Allele Detail
Summary
Symbol: Pgrtm4.2Lyd
Name: progesterone receptor; targeted mutation 4.2, John P Lydon
MGI ID: MGI:4439306
Synonyms: PRd
Gene: Pgr  Location: Chr9:8899834-8968612 bp, + strand  Genetic Position: Chr9, 2.46 cM
Alliance: Pgrtm4.2Lyd page
Uterine defects in Pgrtm4.2Lyd/Pgrtm4.2Lyd and Pgrtm1Bwo/Pgrtm1Bwo mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158406
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into intron 1 and an FRT site flanked neomycin reistance gene cassette with a 5' loxP site was inserted into intron 2. Flp-mediated recombination removed the neo cassette. Exon 2 was removed by cre-mediated recombination. The absence of protein expression was confirmed by immunohistochemistry on uterine sections. (J:158406)
Generation of the Pgrtm4.1Lyd and Pgrtm4.2Lyd alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Pgrtm4.2Lyd
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pgr Mutation:  73 strains or lines available
References
Original:  J:158406 Fernandez-Valdivia R, et al., A mouse model to dissect progesterone signaling in the female reproductive tract and mammary gland. Genesis. 2010 Feb;48(2):106-13
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory