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Tg(CAG-lacZ,-SV40)#Bcv
Transgene Detail
Nomenclature
Symbol: Tg(CAG-lacZ,-SV40)#Bcv
Name: transgene insertion, Barbara C Vanderhyden
MGI ID: MGI:4439280
Synonyms: tgCAG-LS-TAg
Transgene: Tg(CAG-lacZ,-SV40)#Bcv  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe construct contains the early region of SV40 TAg, a beta-geo gene (a fusion of beta-galactosidase and neomycin phosphotransferase genes) expressed from the cytomegalovirus (CMV) early enhancer/chicken beta-actin (CAG) promoter. The beta-geo gene and three downstream polyA signals (3xpolyA) are flanked by loxP sites. Exposure to Cre recombinase results in the deletion of the beta-geo/3xpolyA cassette leading to the TAg expression. Two lines showed reproducible expression of beta-gal in the ovarian surface epithelium (OSE). Of these two lines, only one was found to express SV40 TAg in the OSE after the intrabursal administration of adenovirus expressing Cre recombinase. No line number was given. (J:158388)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:158388 Laviolette LA, et al., 17beta-estradiol accelerates tumor onset and decreases survival in a transgenic mouse model of ovarian cancer. Endocrinology. 2010 Mar;151(3):929-38
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory