Lgi4^tm1Sjm
Targeted Allele Detail

Summary

• Symbol: Lgi4^tm1Sjm
• Name: leucine-rich repeat LGI family, member 4; targeted mutation 1, Sean J Morrison
• MGI ID: MGI:4439269
• Synonyms: Lgi4^LacZ
• Gene: Lgi4 Location: Chr7:30758767-30770360 bp, + strand Genetic Position: Chr7, 19.29 cM
• Alliance: Lgi4^tm1Sjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166449
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The lacZ gene has replaced the first three exons of the endogenous gene so that beta-galactosidase is expressed under control of the endogenous regulatory elements. Flp-mediated recombination removed the neo cassette used for selection. (J:166449)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	81 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgi4 Mutation: 32 strains or lines available

Notes

ES Cell Line = Bruce4.G9, a subline of Bruce 4.

References

• Original: J:166449 Nishino J, et al., Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. J Neurosci. 2010 Nov 10;30(45):15228-40
• All: 1 reference(s)