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Hs2st1tm1.2Je
Targeted Allele Detail
Nomenclature
Symbol: Hs2st1tm1.2Je
Name: heparan sulfate 2-O-sulfotransferase 1; targeted mutation 1.2, Jeffrey D Esko
MGI ID: MGI:4439258
Synonyms: zp3Hs2st-
Gene: Hs2st1  Location: Chr3:144429706-144570181 bp, - strand  Genetic Position: Chr3, 68.89 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158299
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1, which contains the start codon, was removed by cre mediated recombination. Analysis of enzymatic activity and disaccharide analysis confirms grossly defective 2-O-sulfation. (J:158299)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hs2st1 Mutation:  17 strains or lines available
References
Original:  J:158299 Stanford KI, et al., Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance. J Biol Chem. 2010 Jan 1;285(1):286-94
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory