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Targeted Allele Detail
Symbol: Pkdcctm1.1Mask
Name: protein kinase domain containing, cytoplasmic; targeted mutation 1.1, Masaki Kinoshita
MGI ID: MGI:4438609
Synonyms: Vlk-
Gene: Pkdcc  Location: Chr17:83522721-83532499 bp, + strand  Genetic Position: Chr17, 52.25 cM
Germline Transmission:  Earliest citation of germline transmission: J:158147
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 was replaced with an attB1 site, Venus gene, floxed neo cassette, and attB2 site. Cre mediated recombination removed the neo cassette. The absence of transcript expression was confirmed by RT-PCR on E12.5 whole embryo extracts. (J:158147)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 45 assay results
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pkdcc Mutation:  19 strains or lines available
Original:  J:158147 Kinoshita M, et al., The novel protein kinase Vlk is essential for stromal function of mesenchymal cells. Development. 2009 Jun;136(12):2069-79
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
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