Tg(Thy1-TARDBP)6Singh
Transgene Detail

Summary

• Symbol: Tg(Thy1-TARDBP)6Singh
• Name: transgene insertion 6, Samir Kumar-Singh
• MGI ID: MGI:4438491
• Synonyms: TAR6
• Transgene: Tg(Thy1-TARDBP)6Singh Location: unknown
• Alliance: Tg(Thy1-TARDBP)6Singh page

Transgene origin

• Strain of Origin: C57BL/6 and SJL

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-TARDBP)6Singh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TARDBP (23435)

  Tardbp

  (MGI:2387629)

• Mutation details: The cDNA of human TARDBP was driven by Thy1 promoter. Quantitative RT-PCR on brain tissue of 3 week old homozygous mice determined this line to have a 1.2 fold increase over endogenous gene expression. (J:157550)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:157550 Wils H, et al., TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3858-63
• All: 3 reference(s)