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Dkkl1tm1.1Mldp
Targeted Allele Detail
Nomenclature
Symbol: Dkkl1tm1.1Mldp
Name: dickkopf-like 1; targeted mutation 1.1, Melvin DePamphilis
MGI ID: MGI:4438465
Gene: Dkkl1  Location: Chr7:45207519-45212147 bp, - strand  Genetic Position: Chr7, 29.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158272
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to insert loxP sites flanking exons 2-4 of the Dickkopf-Like 1 (Dkkl1) gene, and a frt-flanked neomycin resistance (neo) cassette upstream of the 3' loxP site. Cre mediated recombination removed exons 2 through 4 and the frt-flanked neo cassette. The absence of protein expression was confirmed by immunohistochemistry on testis samples. (J:158272)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dkkl1 Mutation:  9 strains or lines available
References
Original:  J:158272 Kaneko KJ, et al., The acrosomal protein Dickkopf-like 1 (DKKL1) is not essential for fertility. Fertil Steril. 2010 Mar 15;93(5):1526-32
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory