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Edn2tm1.1Nat
Targeted Allele Detail
Nomenclature
Symbol: Edn2tm1.1Nat
Name: endothelin 2; targeted mutation 1.1, Jeremy Nathans
MGI ID: MGI:4438396
Synonyms: ET-2fl, ET-2flox
Gene: Edn2  Location: Chr4:120161206-120167360 bp, + strand  Genetic Position: Chr4, 55.77 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:158269
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe second exon of the targeted gene was flanked by two LoxP sites. Adjacent to the second LoxP site is an Frt site left over after the excision of the PGK-neomycin selectable marker. (J:158269)
Generation of the Edn2tm1.1Nat allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Edn2 Mutation:  13 strains or lines available
References
Original:  J:158269 Nathans J, Direct data submission for Edn2. MGI Direct Data Submission. 2010;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory