Foxd1^{tm2(GFP/cre/ERT2)Amc}
Targeted Allele Detail

Summary

• Symbol: Foxd1^{tm2(GFP/cre/ERT2)Amc}
• Name: forkhead box D1; targeted mutation 2, Andrew P McMahon
• MGI ID: MGI:4437895
• Synonyms: FoxD1-GCE
• Gene: Foxd1 Location: Chr13:98490753-98493213 bp, + strand Genetic Position: Chr13, 51.96 cM
• Alliance: Foxd1^{tm2(GFP/cre/ERT2)Amc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158051
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Foxd1^{tm2(GFP/cre/ERT2)Amc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Foxd1 (MGI:1347463)

• Mutation details: A targeting vector was designed to insert an eGFP/Cre/ERT2 (GCE) fusion protein coding sequence and frt-flanked PGKneobpA selection cassette into the initiation codon of the Forkhead box D1 (Foxd1) targeted gene. (J:158051)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxd1 (mouse) Summary of all recombinase alleles driven by Foxd1. Alliance mouse Foxd1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxd1 Mutation: 11 strains or lines available

References

• Original: J:158051 Humphreys BD, et al., Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol. 2010 Jan;176(1):85-97
• All: 8 reference(s)