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Nr1h4tm1.2Auw
Targeted Allele Detail
Nomenclature
Symbol: Nr1h4tm1.2Auw
Name: nuclear receptor subfamily 1, group H, member 4; targeted mutation 1.2, Johan Auwerx
MGI ID: MGI:4437614
Synonyms: Fxr-
Gene: Nr1h4  Location: Chr10:89454234-89533585 bp, - strand  Genetic Position: Chr10, 44.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157882
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exon 6 was removed by cre mediated recombination from Nr1h4tm1.1Auw. (J:157882)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr1h4 Mutation:  10 strains or lines available
References
Original:  J:157882 Milona A, et al., The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr. Am J Physiol Gastrointest Liver Physiol. 2010 Feb;298(2):G151-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory