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Elavl1tm1.1Dkon
Targeted Allele Detail
Nomenclature
Symbol: Elavl1tm1.1Dkon
Name: ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R); targeted mutation 1, Dimitris L Kontoyiannis
MGI ID: MGI:4437584
Synonyms: Elavl1fl
Gene: Elavl1  Location: Chr8:4285382-4325413 bp, - strand  Genetic Position: Chr8, 2.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:184388
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neomycin cassette was placed upstream of the ATG-containing second exon with a third loxP site placed downstream of the exon. Cre mediated recombination removed the floxed neo cassette leaving the exon floxed. (J:149149, J:184388)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Elavl1 Mutation:  18 strains or lines available
References
Original:  J:184388 Yiakouvaki A, et al., Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis. J Clin Invest. 2012 Jan 3;122(1):48-61
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory