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Targeted Allele Detail
Symbol: Mid1tm1Mero
Name: midline 1; targeted mutation 1, Germana Meroni
MGI ID: MGI:4437430
Gene: Mid1  Location: ChrX:169685199-169990798 bp, + strand  Genetic Position: ChrX, 79.19 cM
Germline Transmission:  Earliest citation of germline transmission: J:157828
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA fragment of the first coding exon including the first ATG was replaced with a neo selection cassette. RT-PCR and immunoblot analysis show the complete absence of the transcript and protein in embryos and adult brains, respectively. (J:157828)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mid1 Mutation:  177 strains or lines available
Original:  J:157828 Lancioni A, et al., Lack of Mid1, the mouse ortholog of the Opitz syndrome gene, causes abnormal development of the anterior cerebellar vermis. J Neurosci. 2010 Feb 24;30(8):2880-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory