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Tg(Lrrk2*G2019S)2Yue
Transgene Detail
Nomenclature
Symbol: Tg(Lrrk2*G2019S)2Yue
Name: transgene insertion 2, Zhenyu Yue
MGI ID: MGI:4437428
Synonyms: FLAG-LRRK2-G2019S, LRRK2-G2019SOE
Transgene: Tg(Lrrk2*G2019S)2Yue  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x C3H)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Lrrk2*G2019S)2Yue expresses 1 gene
 
Mutation detailsA bacterial artificial chromosome (BAC) (#RP23-312I9) containing the entire mouse Lrrk2 (leucine-rich repeat kinase 2) gene was modified by targeted mutation of the Lrrk2 locus to harbor the Lrrk2-G2019S mutation associated with autosomal dominant, late-onset Parkinson's disease originally identified in Spanish families originating from the Basque region. This modified 240 kb BAC contains a FLAG-tag downstream from the start codon. Line 2 was established with expression in cerebral cortex, striatum, substantia nigra, internal capsule, and hippocampus at an approximately 6-8 fold greater level than endogenous mouse Lrrk2. (J:128036)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:128036 Li X, et al., Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. J Neurochem. 2007 Oct;103(1):238-47
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory