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Tg(GFAP-HTT*160Q)31Xjl
Transgene Detail
Nomenclature
Symbol: Tg(GFAP-HTT*160Q)31Xjl
Name: transgene insertion 31, Xiao-Jiang Li
MGI ID: MGI:4437299
Synonyms: GFAP-HD, Htt-160Q
Transgene: Tg(GFAP-HTT*160Q)31Xjl  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/NCrl
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(GFAP-HTT*160Q)31Xjl expresses 1 gene
 
Mutation detailsThe GFAP-HD transgene was designed containing 208 aa of N-terminal human huntingtin (HTT) gene, containing 160 glutamine residues (160Q), driven by the human glial fibrillary acidic protein (GFAP) promoter, followed by a mouse protamine-1 (MP-1) polyadenylation (polyA) signal. (J:156460)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:156460 Bradford J, et al., Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22480-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory