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Targeted Allele Detail
Symbol: Chrm1tm2.1Stl
Name: cholinergic receptor, muscarinic 1, CNS; targeted mutation 2.1, Susumu Tonegawa
MGI ID: MGI:4437231
Gene: Chrm1  Location: Chr19:8663789-8681567 bp, + strand  Genetic Position: Chr19, 5.44 cM
Germline Transmission:  Earliest citation of germline transmission: J:156540
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe single coding exon 1 was floxed and an FRT flanked neo was inserted within intron 1 by homologous recombination. Flp mediated recombination removed the selection cassette. (J:156540)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrm1 Mutation:  14 strains or lines available
Original:  J:156540 Kamsler A, et al., Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus. Proc Natl Acad Sci U S A. 2010 Jan 14;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory