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Pkd1tm1Gztn
Targeted Allele Detail
Nomenclature
Symbol: Pkd1tm1Gztn
Name: polycystin 1, transient receptor poteintial channel interacting; targeted mutation 1, Thomas Natoli
MGI ID: MGI:4437121
Gene: Pkd1  Location: Chr17:24549950-24596514 bp, + strand  Genetic Position: Chr17, 12.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:162080
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Exons 21 through 23 are flanked by loxP sites. (J:162080)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pkd1 Mutation:  99 strains or lines available
Notes
ES Cell Line = AMK.
References
Original:  J:162080 Natoli TA, et al., Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models. Nat Med. 2010 Jul;16(7):788-92
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory